ANIMAL NEUROIMAGING RESEARCH FELLOW

The Melbourne Neuropsychiatry Centre (MNC) is undertaking leading research in psychiatric disorders with an emphasis on longitudinal brain imaging studies to identify neurobiological risk and resilience markers. Together with researchers from the Monash Institute of Pharmaceutical Sciences and the University of Queensland, the University of Melbourne successfully obtained a Program Grant that is currently in its first year of funding. This initiative will build on previous
pioneering work in order to address the following overarching goals:

1) improving understanding of how drugs interact with G-Protein Coupling Receptors (GPCRs) to achieve diverse pharmacology;

2) improving understanding of the link between receptor and cellular behaviour, signaling and disease efficacy; and

3) increasing understanding of drivers of disease, to better treat specific symptom domains and increase understanding of the interplay of disease context on drug responses.

Click here for more information

and see link below to apply

http://jobs.unimelb.edu.au/caw/en/job/899404/animal-neuroimaging-research-fellow

Closing date 12 May 2019

 ___________________________________________________________________________________________________________________________________________

Postgraduate Research Stipend to develop cannabinoids as potential therapeutics to treat myasthenia gravis

This Scholarship will provide a stipend towards the living expenses of a PhD student to learn to use intracellular electrophysiological recordings to develop cannabinoid compounds as potential new drugs to restore synaptic function in mouse models of myasthenia gravis.

Location:

Discipline of Physiology, Faculty of Medicine, Sydney Medical School

http://sydney.edu.au/medicine/physiology

Supervisors: A/Prof William Phillips (Physiology) and A/Prof Stephen Reddel (Medicine, Neurology) University of Sydney.

Synopsis

Myasthenia gravis is a serious paralysing disease caused by failure of synaptic transmission at the neuromuscular junction. New treatments to improve synaptic function are needed, current treatments largely require immunosuppression with substantial risks and limitations.

This Scholarship is available for a PhD student to undertake a project using intracellular electrophysiological recordings to develop and test cannabinoid-like compounds as potential future drugs to treat diseases of the neuromuscular synapse.

The project will build upon recent work of the supervisors (Morsch, Protti, Cheng, Braet, Chung, Reddel & Phillips. 2018. Sci Rep 8, 4685). This exciting study shows that cannabinoids change a fundamental property of synaptic transmission – that the size of the released transmitter quanta, which the name would suggest are meant to be of fixed size – are in fact malleable and altered by cannabinoids, with rapid effects on post synaptic transmission amplitudes. This suggests that cannabinoids could provide rapid benefit without immunosuppression. As the neuromuscular junctions are outside the CNS, peripherally restricted therapeutic cannabinoids could be developed without CNS toxicity.

The candidate will be based in the Discipline of Physiology, University of Sydney. Collaboration will be with the Lambert Initiative, University of Sydney ( https://sydney.edu.au/lambert/) including development of peripherally restricted cannabinoids for testing in this project. The scholarship will help support the living costs of the student while they complete their studies.

Keywords

neurology, neuroimmunology, synapse, neuromuscular junction, acetylcholine, AChR, MuSK, muscle specific tyrosine kinase, myasthenia gravis, neuromuscular disease, muscle, electrophysiology, single fibre, intracellular, electrode, cannabinoid, cannabinoid receptor, lambert initiative,

Other Information

The candidate will learn to master intracellular electrophysiology and pharmacology.
An experienced electrophysiologist will train you during 2019.
Applicants must hold an Honours degree (First Class) or a Master's degree in a related field with a substantial research component, or equivalent such as a medical degree with Honours.
This Stipend Scholarship will provide an annual stipend allowance equivalent to the minimum RTP rate. The recipient may apply for an extension of up to 6 months.
The Scholarship is for commencement by mid 2019 and cannot be deferred or transferred to another area of research.


To apply please email a cover letter indicating why you are interested in the project and attach a copy of your current cv to Bill Phillips (This email address is being protected from spambots. You need JavaScript enabled to view it.) and Stephen Reddel (This email address is being protected from spambots. You need JavaScript enabled to view it.).

 ___________________________________________________________________________________________________________________________________________

NHMRC Early Career Research Fellow – Neurovascular Function

Contribute to The National Health and Medical Research Council funded program for Neurovascular Research

  • Full time, fixed term role for 3 years
  • Based in Hobart City
  • Research into the vascular dysfunction of dementia

About Us

The College of Health and Medicine (CHM) brings together five key entities: the School of Health Sciences, the School of Medicine, the School of Nursing, Menzies Institute for Medical Research and the Wicking Dementia Research and Education Centre. The structure provides the optimal model to boost health and medical research performance and transform health outcomes for the Tasmanian community.

The Opportunity

Reporting to the Senior Research Fellow – Neuroscience, you will have a broad knowledge of neuroscience and vascular cell biology to assist in the contribution to a recently established neurovascular research program.

Key Accountabilities

• Undertake high-quality research of national and international standing
• Contribute to achieving the University’s strategic objectives
• Prepare and submit papers for publication and presentation
• Contribute to the development and maintenance of links inside the University
• Plan, execute and evaluate preclinical studies

Your Application

To be successful in the role, your application will need to demonstrate;
• A PhD or equivalent in neuroscience, vascular biology or a relevant field
• A positive record of, and commitment to research
• Ability to gain external funding and a good publication record
• A record of contributing to building and maintaining links
• Experience in the use of pre-clinical models of Alzheimer’s disease or cerebral ischaemia

Remuneration

Appointment to this role will be at Academic Level A and will have a total remuneration package of up to $105,436
comprising base salary within the range of $66,785 to $90,116 plus 17% superannuation.

How to Apply

• To apply online http://careers.utas.edu.au/cw/en/job/493344/nhmrc-early-career-research-fellowneurovascular-function , please provide your resume, cover letter outlining your suitability and motivation for the role, and your responses to the position/selection criteria
• For further information about this position, please contact Dr Brad Sutherland, Senior Lecturer in Neurosciences,
This email address is being protected from spambots. You need JavaScript enabled to view it. or +61 3 6226 7634.
• Please visit http://www.utas.edu.au/jobs/applying2 for our guide to applying and details on the recruitment
process.

Applications close Monday, 15 April 2019, 11.55pm (AEST)

_________________________________________________________________________________________________________________________________________________________________